Certagen GmbH

H892 Leukoencephalomyelopathy (LEMP)

Background

Leukoencephalomyelopathy (LEMP) is a recessively inherited neurological disorder caused by a mutation identified in the NAPEPLD gene. It is a rare disorder which paralysis dogs at a young age. LEMP affects the white matter (myelin) of the central nervous system. An abnormal structure of myelin causes a short circuit in the conduction of the nerves. As a result, nerve impulses are no longer passed on to the brain once they enter the spinal cord. And vice versa. The body becomes confused and the dogs’ movements become extremely uncoordinated and disturbed.

Leukoencephalomyelopathy is identified by slowly worsening gait abnormalities (like dragging with the paws) and a characteristic pattern on MRI. Dogs with LEMP may become increasingly immobile within a few months once the disease is in the progressive clinical course. In the final fase, affected dogs will be fully paralysed and eventually die.

Until now, there is no effective treatment found for this disease. In most cases, affected dogs are not in pain but are restricted in their daily life.

Test specific information

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Age

Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

PLEASE NOTE
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

Trait or disease of brain and nervous system.

Breed dependence

This DNA test is available for the following breeds: Leonberger. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Swab, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.

An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.

An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.

Inheritance

This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous).

Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.

Severity of Disease

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Code H892

Leukoencephalomyelopathy (LEMP)

€ 50,10 (Incl. 19% VAT)
€ 42,10 (Excl. VAT)
Quantity