Certagen GmbH

H893 Adult Onset Deafness (AOD)


Adult Onset Deafness (AOD) causes hearing loss in the early state of adulthood. It appears at the age of 3-5 years old. This is earlier than typically expected for aging dogs (8-10 years). This condition is similar to the one in humans. It is hard to say when exactly the deafness appears. Most owners do not recognise it immediately because the dog starts the compensates its loss of hearing by looking at the non-verbal language of it’s owner. Symptoms of AOD include no response to sounds, no response when called by name and being difficult to wake.

Test specific information

This test is based on a genome wide association study in which multiple DNA variants in close proximity to the usp31 gene on chromosome 6 were discovered that are related to Early Adult Onset Deafness (EAOD) in border collie. These DNA variants are a “risk factor” and VHLGenetics tests only for the DNA variant that has been published with the "highest risk". The exact mutation(s) that are causative to AOD/EOAD in border collie and/or other breeds are still to be elucidated.


‘Late onset’ – This phrase indicates, that the symptoms of the disease can be detected at a later ages. ‘Late onset’ is the opposite of ‘early onset’, in which symptoms may be present at younger ages. The phrases are used because the mutation causing ´late onset´ symptoms may be different compared to the mutations causing ´early onset´ symptoms.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

Trait or disease of the sense organs (ears, eyes).

Breed dependence

This DNA test is available for the following breeds: Border Collie. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Swab, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.


An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.

An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will also become ill.

An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will also become ill.


This genetic factor is inherited in an autosomal, dominant, mode. This means, that the individual can be free of the mutation (homozygote normal), affected (homozygous affected) or carrier (heterozygous affected). Both carriers and affected individuals will show symptoms of the mutation.

Severity of Disease


Code H893

Adult Onset Deafness (AOD)

€ 50,10 (Incl. 19% VAT)
€ 42,10 (Excl. VAT)