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Coat colour in dogs is controlled by a wide range of different genes working together.
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Spezifikationen
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Tupfer, EDTA Blut, Heparin Blut, Sperma, Gewebe |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Allgemeine Informationen
Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The I-Locus, a.k.a intensity dilution/intensity/ dilution, corresponds to the gene MFSD12, which is involved in pigment production and distribution. A dominant mutation to this gene, designated as I, further dilutes the phaeomelanin (light pigment) of affected dogs, which can lighten a yellow or red coat to cream or white. The unaffected recessive allele, designated as i, results in normal coloration.
Klinische Merkmale
Affected dogs (I/I or I/i) develop lightened coats (usually described as pale cream or white), as long as they are also affected by the recessive variant of the E-Locus (e/e). Affected dogs are not albino, and should retain a dark coloration of the lips, paw pads, eye rims, etc.
Likewise, dogs with a black-and-tan or saddle tan phenotype will display creamy instead of tan fur.
Zusätzliche Information
Die Fellfarbe ist ein kompliziertes Merkmal, das eine Kombination mehrerer verschiedener Gene beinhaltet. Das Testen auf eine Reihe verschiedener Loci liefert die vollständigste Vorhersage der Fellfarbgenetik eines Hundes.
Verweise
Pubmed ID: 31117290
Omia ID: 2197
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