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Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs.
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Spezifikationen
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Tupfer, EDTA Blut, Heparin Blut, Sperma, Gewebe |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Allgemeine Informationen
Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs. Caused by an X-linked recessive mutation to the gene F8, the disease strongly impairs the blood’s ability to clot, which can lead to severe symptoms such as spontaneous internal bleeding, or uncontrolled bleeding after injury or surgery.
This specific variant of the disease, known as HEMA-2, is one of two to occur in the German Shepherd. Related variants are also found in the Irish Setter, Miniature Schnauzer, Boxer, Old English Sheepdog and the Rhodesian Ridgeback.
Klinische Merkmale
The main symptom of haemophilia is easy or spontaneous bleeding and/or bruising. Affected dogs may develop hematomas (soft, blood-filled swellings under the skin, bruises), bleed from the gums, or experience internal bleeding in the joints (causing lameness) or in the chest or abdomen (which can be life-threatening). Bleeding after trauma or a medical procedure is also likely to be severe.
Zusätzliche Information
Verweise
Pubmed ID: 25040606
Omia ID: 437
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