Von Willebrand Erkrankung Typ 1

Von Willebrand Disease (vWD) is a group of bleeding disorders caused by deficiency in the von Willebrand factor (vWF), which results in poorly functioning blood platelets and can lead to uncontrolled bleeding. Type I Von Willebrand Disease (vWD I) is found in a wide variety of breeds, including the Doberman, Poodle and Corgi.

The disorder is caused by a recessive mutation to the gene VWF. However, in the Doberman and Kromfohrländer, the disease has been found to inherit in an incomplete dominant manner instead. (That is, dogs of these breeds may sometimes develop the disorder while having only one copy of the mutation.)